Mineralocorticoid receptor activation in obesity hypertension
نویسندگان
چکیده
منابع مشابه
Mineralocorticoid receptor antagonism attenuates experimental pulmonary hypertension.
Mineralocorticoid receptor (MR) activation stimulates systemic vascular and left ventricular remodeling. We hypothesized that MR contributes to pulmonary vascular and right ventricular (RV) remodeling of pulmonary hypertension (PH). We evaluated the efficacy of MR antagonism by spironolactone in two experimental PH models; mouse chronic hypoxia-induced PH (prevention model) and rat monocrotalin...
متن کاملEndothelial mineralocorticoid receptor activation mediates endothelial dysfunction in diet-induced obesity
AIMS Aldosterone plays a crucial role in cardiovascular disease. 'Systemic' inhibition of its mineralocorticoid receptor (MR) decreases atherosclerosis by reducing inflammation and oxidative stress. Obesity, an important cardiovascular risk factor, is an inflammatory disease associated with increased plasma aldosterone levels. We have investigated the role of the 'endothelial' MR in obesity-ind...
متن کاملMineralocorticoid receptor activation and mineralocorticoid receptor antagonist treatment in cardiac and renal diseases.
C ardiac and renal diseases remain major challenges for healthcare systems in developed countries and commonly coexist, with a disorder in the heart or kidney often leading to secondary dysfunction or injury in the other organ. Indeed, the term cardiorenal syndrome has been introduced to describe the broad spectrum of disease involving both the heart and kidneys. 1 Aldosterone is a steroid horm...
متن کاملMineralocorticoid receptor activation and oxidative stress.
The spontaneously hypertensive rat (SHR) has been extensively used in studies of hypertension for decades. More recently, a leptin receptor– deficient SHR (SHR/ NDmer-cp; SHR/cp) has been developed as a model for the human metabolic syndrome, characterized by elevated blood pressure, visceral obesity, glucose intolerance, and dyslipidemia. In this issue of Hypertension Nagase et al1 have used t...
متن کاملMineralocorticoid receptor activation: a major contributor to salt-induced renal injury and hypertension in young rats.
Excessive salt intake is known to preferentially increase blood pressure (BP) and promote kidney damage in young, salt-sensitive hypertensive human and animal models. We have suggested that mineralocorticoid receptor (MR) activation plays a major role in kidney injury in young rats. BP and urinary protein were compared in young (3-wk-old) and adult (10-wk-old) uninephrectomized (UNx) Sprague-Da...
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ژورنال
عنوان ژورنال: Hypertension Research
سال: 2009
ISSN: 0916-9636,1348-4214
DOI: 10.1038/hr.2009.86